The Nuke Brothers (2005)

Thirty-five years after a nuclear and pharmaceutical apocalypse transformed Earth into a desolate wasteland, Duke and Zeph navigate a dangerous world. This film follows their comical yet perilous journey for survival. They face violent scavengers, mutated creatures, deranged individuals, robots, criminals, ruthless leaders, and even extraterrestrial visitors, all while uncovering the enigmatic secrets of the old world – strange artifacts and lost technologies from before the war.